Causation of potential drug to drug interactions alerts, alert overrides, and adverse drug events in critical cardiac patients

Abstract Background Drug-drug interactions (DDIs) leading to adverse drug events (ADEs) are of special interest because they represent preventable medication errors. Preventable ADE can result in errors involving the manifestation patient outcomes. Given high complexity critically ill cardiac patients, it is important learn how Clinical Drug Decision Support System (CDDSS) affects outcomes this population and number alerts that likely be safely suppressed. Purpose Identify DDIs clinically detected review appropriateness doctor's actions potential (PDDIs) alert. Study Design: This a prospective observational study conducted at critical care unit (CCU) selected tertiary center for duration six months. Methods Physicians treating patients were presented with PDDIs data which acquired from two commercially available CDDSS. The relationship between decision prescribe factors hypothesized affect physicians' decisions was examined. Results Evaluation 709 profiles conducted, resulting 521 assessed having had one or more 87% them being influenced by polypharmacy. Ninety-one (17.5%) associated DDIs. Of total 3284 alerts, 95.5% overridden. as an outcome inappropriate override has resulted 83.1%. (236/284) Whereas appropriate overrides irrelevant 16.9% (48/284). Conclusion Poor preventive taken doctors caused drug-related harm despite CDDSS place. suggests application minimize alerting physicians potentially unsafe situations. Funding Acknowledgement Type funding sources: Public Institution(s). Main source(s): International Medical UniversityNational Heart Institute